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KMID : 1001020140120020047
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Journal of Urologic Oncology
2014 Volume.12 No. 2 p.47 ~ p.53
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Indication of Prostate Biopsy
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Ku Ja-Yoon
Jeon Tae-Kyung
Ha Hong-Koo
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Abstract
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The prevalence of prostate cancer is stiffly increasing in Korea. In contrasts to the frequency of occurrence, there is no definite guideline for the cut off value of serum PSA. So, we reviewed the usefulness of serum PSA and recently reported guidelines in the prostate cancer detection. Nowadays, the cut off value of PSA continued to change, moreover, it is difficult to satisfied both sensitivity and specificity, at the same time. Also, the value of PSA relies on the assay method or laboratory. Various methods such as the percent of free PSA, PSA velocity and PSA doubling time have been used to enhance the detection rate during prostate biopsy. However, these methods did not make certainty in deciding whether performing the prostate biopsy. To complement the uncertainty of PSA and its derivatives, the new ways such as proPSA, PCA3 and gene fusion have been recently documented. Currently, the clearly indication of prostate biopsy is placed in controversy. Therefore, in the future, new methods to overcome non-specificity of PSA should be considered
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KEYWORD
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Prostate specific antigen, Prostate cancer screening, Prostate needle biopsy, Values clarification, Prostate cancer, Indication
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